Prognostic value of microRNA-125a expression status in molecular groups of pediatric medulloblastoma.

Soheir M HamamEman AbdelzaherShady H FadelRasha A NassraHend A Sharafeldin

Published in: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (2023)

MicroRNA-125a expression was significantly lower in categories of pediatric MB patients with worse prognosis namely LC/A histology and the non-WNT/non-SHH group suggesting a pathogenetic role. MicroRNA-125a expression could represent a promising prognostic factor and a potential therapeutic target in the non-WNT/non-SHH group which represents the most common and the most heterogeneous group of pediatric MBs coupled with the highest rates of disseminated disease. Preoperative tumor size represents an independent prognostic factor.

Keyphrases

prognostic factors
poor prognosis
stem cells
binding protein
long non coding rna
patients undergoing
mass spectrometry
climate change
childhood cancer