Prognostic and therapeutic role of vitamin D in COVID-19: systematic review and meta-analysis.

Harsha Anuruddhika DissanayakeNipun Lakshitha de SilvaManilka SumanatillekeSawanawadu Dilantha Neomal de SilvaKavinga Kalhari Kobawaka GamageChinthana DematapitiyaDaya Chandrani KuruppuPriyanga RanasingheSivatharshya PathmanathanPrasad Katulanda

Published in: The Journal of clinical endocrinology and metabolism (2021)

Multiple observational studies involving nearly two million adults suggest vitamin D deficiency/insufficiency increases susceptibility to COVID-19 and severe COVID-19, although with a high risk of bias and heterogeneity. Association with mortality was less robust. Heterogeneity in RCTs precluded their meta-analysis.

Keyphrases

coronavirus disease
sars cov
systematic review
single cell
early onset
cardiovascular events
type diabetes
cardiovascular disease
randomized controlled trial
risk factors
meta analyses
coronary artery disease
drug induced