Thymoquinone Suppresses Cell Proliferation and Enhances Apoptosis of HL60 Leukemia Cells through Re-Expression of JAK/STAT Negative Regulators.
Belal AlmajaliHamid Ali Nagi Al-JamalWan Rohani Wan TaibImilia IsmailMuhammad Farid JohanAbd Almonem DoolaaneaWisam Nabeel IbrahimSyed Ahmad TajudinPublished in: Asian Pacific journal of cancer prevention : APJCP (2021)
TQ potentially inhibited HL60 cell proliferation and significantly increased apoptosis with re-expression of JAK/STAT-negative regulator genes suggesting that TQ could be a new therapeutic candidate for leukemia therapy.<br />.
Keyphrases
- cell cycle arrest
- cell proliferation
- pi k akt
- poor prognosis
- cell death
- endoplasmic reticulum stress
- induced apoptosis
- oxidative stress
- signaling pathway
- acute myeloid leukemia
- bone marrow
- cell cycle
- transcription factor
- binding protein
- stem cells
- gene expression
- long non coding rna
- genome wide
- mesenchymal stem cells
- genome wide identification
- bioinformatics analysis
- smoking cessation
- replacement therapy