Precision synbiotics increase gut microbiome diversity and improve gastrointestinal symptoms in a pilot open-label study for autism spectrum disorder.
Joann PhanDiana C CalvoDivya NairSuneer JainThibaut MontagneSummer DietscheKelsey BlanchardShirin TreadwellJames B AdamsRosa Krajmalnik-BrownPublished in: mSystems (2024)
Autism spectrum disorder (ASD) is prevalent in 1 out of 36 children in the United States and contributes to health, financial, and psychological burdens. Attempts to identify a gut microbiome signature of ASD have produced varied results. The limited pre-clinical and clinical population sizes have hampered the success of these trials. To understand the microbiome associated with ASD, we employed whole metagenomic shotgun sequencing to classify microbial composition and genetic functional potential. Despite being one of the most extensive ASD post-synbiotic assessment studies, the results highlight the complexity of performing such a case-control supplementation study in this population and the potential for a future therapeutic approach in ASD.
Keyphrases
- autism spectrum disorder
- attention deficit hyperactivity disorder
- intellectual disability
- case control
- open label
- healthcare
- clinical trial
- young adults
- randomized controlled trial
- mental health
- gene expression
- study protocol
- microbial community
- radiation therapy
- genome wide
- risk assessment
- copy number
- single cell
- rectal cancer
- double blind
- antibiotic resistance genes
- health insurance
- patient reported