Intramolecular G-quadruplex-hairpin loop structure competition of a GC-rich exon region in the TMPRSS2 gene.
Wataru SugimotoNatsuki KinoshitaMinori NakataTatsuya OhyamaNaoki SugimotoTakahito NishikataNaoki SugimotoDaisuke MiyoshiKeiko KawauchiPublished in: Chemical communications (Cambridge, England) (2021)
We identified cytosine-rich regions adjacent to guanine-rich regions in protease genes. A typical GC-rich sequence derived from the TMPRSS2 gene showed structural competition between a G-quadruplex and a hairpin loop, and this competition significantly affected transcription efficiency. These results suggest an impact of neighboring sequences on the gene expression of guanine-rich sequences.