Performance of clinical signs and symptoms, rapid and reference laboratory diagnostic tests for diagnosis of human African trypanosomiasis by passive screening in Guinea: a prospective diagnostic accuracy study.
Oumou CamaraMamadou CamaraLaura Cristina FalzonHamidou IlboudoJacques KaboréCharlie Franck Alfred CompaoréEric Maurice FèvrePhilippe BüscherBruno BuchetonVeerle LejonPublished in: Infectious diseases of poverty (2023)
Presence of swollen lymph nodes, important weight loss, severe itching or motor disorders are simple but accurate clinical criteria for HAT referral in HAT endemic areas in Guinea. Diagnostic performances of HAT Sero-K-Set and SD Bioline HAT are sufficient for referring positives to microscopy. Trypanolysis on DBS may discriminate HAT patients from false RDT positives. Trial registration The trial was registered under NCT03356665 in clinicaltrials.gov (November 29, 2017, retrospectively registered https://clinicaltrials.gov/ct2/show/NCT03356665 ).
Keyphrases
- lymph node
- weight loss
- end stage renal disease
- study protocol
- high resolution
- clinical trial
- phase iii
- ejection fraction
- endothelial cells
- primary care
- phase ii
- chronic kidney disease
- bariatric surgery
- prognostic factors
- peritoneal dialysis
- randomized controlled trial
- single molecule
- magnetic resonance imaging
- patient reported outcomes
- high speed
- induced pluripotent stem cells
- gastric bypass
- open label
- adipose tissue
- single cell
- insulin resistance
- mass spectrometry
- body mass index
- sleep quality
- sensitive detection
- quantum dots
- sentinel lymph node
- pet ct
- double blind