Soluble Alpha Klotho in Acromegaly: Comparison With Traditional Markers of Disease Activity.

Júnia R O L SchweizerKatharina SchilbachMichael HaeneltAlexandre V GiannettiMariana F BizziBeatriz S SoaresEduardo PaulinoJochen SchopohlSylvère StörmannAntônio Ribeiro-OliveiraMartin Bidlingmaier

Published in: The Journal of clinical endocrinology and metabolism (2021)

Our data support sαKL as a biomarker to assess disease activity in acromegaly. sαKL exhibits close association with GH secretory status, large dynamic range, and robustness toward biological confounders. Its measurement could be helpful particularly when GH and IGF-I provide discrepant information.

Keyphrases

disease activity
growth hormone
rheumatoid arthritis
systemic lupus erythematosus
rheumatoid arthritis patients
ankylosing spondylitis
juvenile idiopathic arthritis
electronic health record
big data
health information
social media
signaling pathway
deep learning