Distinct BTK inhibitors differentially induce apoptosis but similarly suppress chemotaxis and lipid accumulation in mantle cell lymphoma.

Zhuojun LiuJia LiuTianming ZhangLin LiShuo ZhangHao JiaYuanshi XiaMingxia ShiJing ZhangShuhua YueXiaofang ChenJian Yu

Published in: BMC cancer (2021)

BTKi demonstrated differential capacities to induce MCL-cell apoptosis due to their distinct capabilities to regulate the expression of apoptosis-related genes, and similar biological and molecular inhibitory effects on MCL-cell chemotaxis and LD accumulation.

Keyphrases

endoplasmic reticulum stress
cell cycle arrest
oxidative stress
cell death
poor prognosis
single cell
cell proliferation
cell therapy
tyrosine kinase
pi k akt
binding protein
single molecule
long non coding rna