Beyond average outcomes: A latent profile analysis of diverse developmental trajectories in preterm and early term-born children from the Adolescent Brain Cognitive Development study.
Iris MenuLanxin JiTanya BhatiaMark DuffyCassandra L HendrixMoriah E ThomasonPublished in: Child development (2024)
Preterm birth poses a major public health challenge, with significant and heterogeneous developmental impacts. Latent profile analysis was applied to the National Institutes of Health Toolbox performance of 1891 healthy prematurely born children from the Adolescent Brain and Cognitive Development study (970 boys, 921 girls; 10.00 ± 0.61 years; 1.3% Asian, 13.7% Black, 17.5% Hispanic, 57.0% White, 10.4% Other). Three distinct neurocognitive profiles emerged: consistently performing above the norm (19.7%), mixed scores (41.0%), and consistently performing below the norm (39.3%). These profiles were associated with lasting cognitive, neural, behavioral, and academic differences. These findings underscore the importance of recognizing diverse developmental trajectories in prematurely born children, advocating for personalized diagnosis and intervention to enhance care strategies and long-term outcomes for this heterogeneous population.
Keyphrases
- gestational age
- preterm birth
- low birth weight
- young adults
- public health
- preterm infants
- mental health
- healthcare
- randomized controlled trial
- depressive symptoms
- white matter
- resting state
- palliative care
- type diabetes
- multiple sclerosis
- risk assessment
- insulin resistance
- adipose tissue
- functional connectivity
- climate change
- pain management
- childhood cancer
- glycemic control