A Unique Cellular Organization of Human Distal Airways and Its Disarray in Chronic Obstructive Pulmonary Disease.

Samir RustamYang HuSeyed Babak MahjourAndre F RendeiroHiranmayi RavichandranAndreacarola UrsoFrank D'OvidioFernando J MartinezNasser K AltorkiBradley W RichmondVasiliy PolosukhinJonathan A KropskiTimothy S BlackwellScott H RandellOlivier ElementoRenat Shaykhiev

Published in: American journal of respiratory and critical care medicine (2023)

Altered maintenance of the unique cellular organization of pre-TB/TBs, including loss of the region-specific epithelial differentiation in these bronchioles, represents the cellular manifestation and likely the cellular basis of distal airway remodeling in COPD.

Keyphrases

endothelial cells
chronic obstructive pulmonary disease
minimally invasive
cystic fibrosis
induced pluripotent stem cells
pluripotent stem cells