RUNX2 interacts with BRG1 to target CD44 for promoting invasion and migration of colorectal cancer cells.

Xiaodong YanDali HanZhiqiang ChenChao HanWei DongLi HanLei ZouJianbo ZhangYan LiuJie Chai

Published in: Cancer cell international (2020)

Our cumulative findings suggest that RUNX2 and BRG1 can form a compact complex to regulate the transcription and expression of CD44, which has possible involvement in the invasion and migration of CRC cells.

Keyphrases

transcription factor
cell migration
induced apoptosis
poor prognosis
binding protein
cell cycle arrest
nk cells
cell death
long non coding rna
cell proliferation
pi k akt