Mitochondrial GRIM-19 deficiency facilitates gastric cancer metastasis through oncogenic ROS-NRF2-HO-1 axis via a NRF2-HO-1 loop.

Xin WangTingbo YeBingqian XueMeihua YangRui LiXiaohui XuXin ZengNa TianLiming BaoYi Huang

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2020)

Our data suggest that GRIM-19 deficiency accelerates GC metastasis through the oncogenic ROS-NRF2-HO-1 axis via a positive-feedback NRF2-HO-1 loop. Therefore, this study not only offers novel insights into the role of oncogenic NRF2 in tumor progression, but also provides new strategies to alleviate the dark side of NRF2 by targeting HO-1.

Keyphrases

oxidative stress
transcription factor
dna damage
pi k akt
cell death
poor prognosis
high resolution
deep learning
long non coding rna