A novel HSF1 activator ameliorates nonalcoholic steatohepatitis by stimulating mitochondrial adaptive oxidation.

Yong RaoChan LiYu-Tao HuYao-Hao XuBing-Bing SongShi-Yao GuoZhi JiangDan-Dan ZhaoShuo-Bin ChenJia-Heng TanShi-Liang HuangQing-Jiang LiXiao-Jun WangYing-Jun ZhangJi-Ming YeShuo-Bin Chen

Published in: British journal of pharmacology (2021)

Activation of HSF1 is a practicable therapeutic approach for NASH treatment via the HSF1/PGC-1α/mitochondrial axis, and SYSU-3d would take into consideration as a potential candidate for the treatment of NASH.

Keyphrases

heat shock
oxidative stress
skeletal muscle
mouse model
risk assessment
nuclear factor
inflammatory response
heat stress