Associations of serum soluble Fas and Fas ligand (FasL) with outcomes in systemic lupus erythematosus.

Serum sFas is associated with active renal SLE, and active disease and flare over time, while sFasL/sFas ratio is negatively associated with disease activity and organ damage accrual. Treatments correcting abnormal levels of sFas/FasL may be worthy of evaluation in SLE.