Biocompatible Porphyrin-Peptide Conjugates as Theranostic Agents Targeting the Epstein-Barr Virus.
Xiong LiChen XieShuai ZhaWing Sze TamMingjun JiangKa-Leung WongPublished in: ChemPlusChem (2022)
Epstein-Barr virus (EBV) is a common human-infected virus related to many diseases and cancers. Recently, some peptides have been found to serve targeting and therapeutic roles by inhibiting EBNA1, an oncoprotein of the EBV. We herein report the conjugation of the EBNA1-targeting peptides and porphyrins which can bring synergistic effects by both introducing more specific treatments (photodynamic therapy) and improving the biocompatibility of the photosensitizer and the peptides. One of our compounds exhibited significant photo-cytotoxicity where the Lethal Concentration 50 (LC 50 )=6.1 μM in EBV-positive cells. Besides, in vitro cell imaging and co-staining can also be achieved simultaneously and suggested the binding inside nucleus.
Keyphrases
- epstein barr virus
- photodynamic therapy
- cancer therapy
- diffuse large b cell lymphoma
- fluorescence imaging
- endothelial cells
- induced apoptosis
- amino acid
- drug delivery
- signaling pathway
- high resolution
- cell cycle arrest
- single cell
- mesenchymal stem cells
- cell therapy
- young adults
- binding protein
- cell death
- endoplasmic reticulum stress
- drug release
- pluripotent stem cells
- tandem mass spectrometry