The effects of the β 1 -adrenergic receptor antagonist bisoprolol administration on mirabegron-stimulated human brown adipose tissue thermogenesis.
Lauralyne DumontAlexandre CaronGabriel RichardEtienne CroteauMélanie FortinFrédérique FrischSerge PhoenixStéphanie DubreuilBrigitte GuérinÉric E TurcotteAndré C CarpentierDenis P BlondinPublished in: Acta physiologica (Oxford, England) (2024)
The administration of bisoprolol decreases the adverse cardiovascular effects of mirabegron. However, the provided dose also blunted the mirabegron-stimulated increase in BAT lipolysis, thermogenesis, and glucose uptake. The attenuation in BAT blood flow induced by the large dose of bisoprolol may have limited BAT thermogenesis.