Metal and oxidative potential exposure through particle inhalation and oxidative stress biomarkers: a 2-week pilot prospective study among Parisian subway workers.
Jean-Jacques SauvainMaud HemmendingerThomas CharreauValérie JouanniqueAmélie DebatisseGuillaume SuarezNancy B HopfIrina Guseva CanuPublished in: International archives of occupational and environmental health (2024)
Associations between MDA in both EBC and urine gave opposite response for subway particles containing Zn versus Cu. This diverting Zn and Cu pattern was also observed for 8-OHdG and urinary concentrations of these two metals. Overall, MDA and 8-OHdG responses were sensitive for same-day metal exposures in both matrices. We recommend MDA and 8-OHdG in large field studies to account for oxidative stress originating from metals in inhaled particulate matter.
Keyphrases
- particulate matter
- oxidative stress
- air pollution
- breast cancer cells
- human health
- heavy metals
- health risk assessment
- cell cycle arrest
- dna damage
- health risk
- risk assessment
- ischemia reperfusion injury
- diabetic rats
- induced apoptosis
- cystic fibrosis
- study protocol
- cell death
- climate change
- metal organic framework
- clinical trial
- randomized controlled trial
- case control
- cell proliferation
- endoplasmic reticulum stress