Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 Isolates.
Ahmed M MoustafaColleen BiancoLidiya DenuAzad AhmedSusan E CoffinBrandy NeideJohn EverettShantan ReddyEmilie RabutJasmine DeseignoraMichael D FeldmanKyle G RodinoFrederic D BushmanRebecca M HarrisJosh Chang MellPaul J PlanetPublished in: Open forum infectious diseases (2021)
We report the genome of a B.1.1.7+E484K severe acute respiratory syndrome coronavirus 2 from Southeastern Pennsylvania and compare it with all high-coverage B.1.1.7+E484K genomes (n = 235) available. Analyses showed the existence of at least 4 distinct clades of this variant circulating in the United States and the possibility of at least 59 independent acquisitions of the E484K mutation.