ets1 associates with KMT5A to participate in high glucose-mediated EndMT via upregulation of PFN2 expression in diabetic nephropathy.
Lihong LuZiwen ZhongJiahui GuKe NanMinmin ZhuChanghong MiaoPublished in: Molecular medicine (Cambridge, Mass.) (2021)
The present study indicated that ets1 cooperated with KMT5A to transcribe PFN2, thus contributing to hyperglycemia-induced EndMT in the glomerular endothelial cells of DN patients and rats. Trial registration ChiCTR, ChiCTR2000029425. 2020/1/31, http://www.chictr.org.cn/showproj.aspx?proj=48548.
Keyphrases
- high glucose
- endothelial cells
- diabetic nephropathy
- end stage renal disease
- poor prognosis
- transcription factor
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- clinical trial
- prognostic factors
- cell proliferation
- vascular endothelial growth factor
- squamous cell carcinoma
- lymph node metastasis
- patient reported outcomes
- oxidative stress
- binding protein