Distinct pathophysiological pathways in women and men with heart failure.
Alice RaveraBernadet T SantemaRudolf A de BoerStefan D AnkerNilesh J SamaniChim C LangLeong L NgJohn G F ClelandKenneth DicksteinCarolyn Su Ping LamHarriette Gillian Christine Van SpallGerasimos FilippatosDirk J van VeldhuisenMarco MetraAdriaan A VoorsIziah E SamaPublished in: European journal of heart failure (2022)
In two independent cohorts of HF patients, biomarkers associated with lipid metabolic pathways were observed in women, while biomarkers associated with neuro-inflammatory response were more active in men. Differences in inflammatory and metabolic pathways may contribute to sex differences in clinical phenotype observed in HF, and provide useful insights towards development of tailored HF therapies.
Keyphrases
- heart failure
- inflammatory response
- acute heart failure
- polycystic ovary syndrome
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- pregnancy outcomes
- middle aged
- prognostic factors
- peritoneal dialysis
- oxidative stress
- left ventricular
- type diabetes
- smoking cessation
- immune response
- cervical cancer screening
- fatty acid
- breast cancer risk
- pregnant women
- toll like receptor
- cardiac resynchronization therapy