The function of LncRNA-ATB in cancer.
Amir AnbiyaieeMohammad RamaziiSiamak Soltani BajestaniSeyed Mohammadmahdi MeybodiMona KeivanSeyed Esmaeil KhoshnamMaryam FarzanehPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2022)
Cancer as a progressive and complex disease is caused by early chromosomal changes and stimulated cellular transformation. Previous studies reported that long non-coding RNAs (lncRNAs) play pivotal roles in the initiation, maintenance, and progression of cancer cells. LncRNA activated by TGF-β (ATB) has been shown to be dysregulated in different types of cancer. Aberrant expression of lncRNA-ATB plays an important role in the progression of diverse malignancies. High expression of LncRNA-ATB is associated with cancer cell growth, proliferation, metastasis, and EMT. LncRNA-ATB by targeting various signaling pathways and microRNAs (miRNAs) can trigger cancer pathogenesis. Therefore, lncRNA-ATB can be a novel target for cancer prediction and diagnosis. In this review, we will focus on the function of lncRNA-ATB in various types of human cancers.
Keyphrases
- long non coding rna
- papillary thyroid
- poor prognosis
- squamous cell
- signaling pathway
- long noncoding rna
- endothelial cells
- childhood cancer
- epithelial mesenchymal transition
- gene expression
- lymph node metastasis
- multiple sclerosis
- copy number
- young adults
- binding protein
- cell proliferation
- transforming growth factor
- case control