SOD3 induces a HIF-2α-dependent program in endothelial cells that provides a selective signal for tumor infiltration by T cells.
Lorena Carmona-RodríguezDiego Martínez-ReyMaria Jesús Fernández-AceñeroAlicia González-MartínMateo Paz-CabezasNoe Rodríguez-RodríguezBeatriz Pérez-VillamilMaria Eugenia SáezEduardo Díaz-RubioEmilia MiraSantos MañesPublished in: Journal for immunotherapy of cancer (2021)
Our findings suggest that SOD3-induced upregulation of LAMA4 in endothelial cells boosts selective tumor infiltration by T lymphocytes, thus transforming immunologically "cold" into "hot" tumors. High SOD3 levels are associated with human colon cancer infiltration by CD8+ T cells, with potential consequences for the clinical outcome of these patients. Our results also uncover a cell type-specific, distinct activity of the WNT pathway for the regulation of T cell infiltration into tumors.
Keyphrases
- endothelial cells
- high glucose
- amyotrophic lateral sclerosis
- end stage renal disease
- ejection fraction
- vascular endothelial growth factor
- newly diagnosed
- cell proliferation
- chronic kidney disease
- stem cells
- quality improvement
- poor prognosis
- peritoneal dialysis
- patient reported outcomes
- diabetic rats
- oxidative stress
- risk assessment