The Role of HO-1 and Its Crosstalk with Oxidative Stress in Cancer Cell Survival.
Shih-Kai ChiangShuen-Ei ChenLing-Chu ChangPublished in: Cells (2021)
Heme oxygenases (HOs) act on heme degradation to produce carbon monoxide (CO), free iron, ferritin, and biliverdin. Upregulation of cellular HO-1 levels is signature of oxidative stress for its downstream effects particularly under pro-oxidative status. Subcellular traffics of HO-1 to different organelles constitute a network of interactions compromising a variety of effectors such as pro-oxidants, ROS, mitochondrial enzymes, and nucleic transcription factors. Some of the compartmentalized HO-1 have been demonstrated as functioning in the progression of cancer. Emerging data show the multiple roles of HO-1 in tumorigenesis from pathogenesis to the progression to malignancy, metastasis, and even resistance to therapy. However, the role of HO-1 in tumorigenesis has not been systematically addressed. This review describes the crosstalk between HO-1 and oxidative stress, and following redox regulation in the tumorigenesis. HO-1-regulated signaling pathways are also summarized. This review aims to integrate basic information and current progress of HO-1 in cancer research in order to enhance the understandings and facilitate following studies.
Keyphrases
- oxidative stress
- pi k akt
- signaling pathway
- papillary thyroid
- dna damage
- transcription factor
- squamous cell
- cell proliferation
- ischemia reperfusion injury
- diabetic rats
- squamous cell carcinoma
- lymph node metastasis
- healthcare
- poor prognosis
- endoplasmic reticulum stress
- health information
- deep learning
- anti inflammatory
- bone marrow
- heat shock protein
- childhood cancer
- heat shock