LEF1 isoforms regulate cellular senescence and aging.
Minxue JiaKhaled SayedMaria G KapetanakiWilliam DionLorena RosasSaad IrfanEleanor ValenziAna L MoraRobert A LafyatisMauricio RojasBokai ZhuPanayiotis V BenosPublished in: bioRxiv : the preprint server for biology (2023)
Collectively, our results suggest that the LEF1 is a key factor of aging, and its differential regulation is associated with human and murine cellular senescence.