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Vitamin D receptor gene is epigenetically altered and transcriptionally up-regulated in multiple sclerosis.

Teresa AyusoPatricia AznarLuis SorianoAnder OlaskoagaMiren RoldánMaría OtanoIratxe AjuriaGerardo SorianoFrancisco LacruzMaite Mendioroz
Published in: PloS one (2017)
An alternative promoter of the VDR gene shows altered DNA methylation levels in patients with multiple sclerosis, and it is associated with VDR mRNA upregulation. This locus may represent a candidate regulatory element in the genome relevant to MS pathogenesis.
Keyphrases
  • dna methylation
  • genome wide
  • multiple sclerosis
  • transcription factor
  • copy number
  • gene expression
  • genome wide identification
  • mass spectrometry
  • cell proliferation
  • poor prognosis
  • signaling pathway
  • white matter