GBA1 inactivation in oligodendrocytes affects myelination and induces neurodegenerative hallmarks and lipid dyshomeostasis in mice.
Ilaria GregorioLoris RussoEnrica TorrettaPietro BarbaciniGabriella ContariniGiada PacinelliDario BizzottoManuela MoriggiPaola BraghettaFrancesco PapaleoCecilia GelfiEnrico MoroMatilde CesconPublished in: Molecular neurodegeneration (2024)
Our study sheds light on the contribution of oligodendrocytes in GBA1-related diseases and supports the need for better characterizing oligodendrocytes as actors playing a role in neurodegenerative diseases, also pointing at them as potential novel targets to set a brake to disease progression.