Apheresis causes complement deposition on red blood cells (RBCs) and RBC antigen alterations, possibly inducing enhanced clearance.
Djuna Z de BackShahryar G NezjadBoukje M BeugerMartijn VeldhuisEls CliffordFatima Ait IchouJeffrey BerghuisMya GoEric GouwerokSanne MeindertsHans VrielinkWim de KortDirk de KorteMarian van KraaijRobin van BruggenPublished in: Transfusion (2018)
The increase in complement deposition and the decrease in the expression of CD59 suggests that RBC clearance might be enhanced after return to the donor. Possible side effects due to an increase in hemolysis after Trima Accel plateletpheresis should be further investigated.