Cell cycle inhibition reduces inflammatory responses, neuronal loss, and cognitive deficits induced by hypobaria exposure following traumatic brain injury.
Jacob W SkoviraJunfang WuJessica J MatyasAlok KumarMarie HanscomShruti V KabadiRaymond FangAlan I FadenPublished in: Journal of neuroinflammation (2016)
HB exposure following TBI increases CCA, neuroinflammation, and associated neuronal cell loss. These changes and post-traumatic cognitive deficits are reduced by CDK inhibition; such drugs may therefore serve to protect TBI patients requiring aeromedical evacuation.
Keyphrases
- traumatic brain injury
- cell cycle
- end stage renal disease
- cell proliferation
- chronic kidney disease
- severe traumatic brain injury
- ejection fraction
- newly diagnosed
- cerebral ischemia
- peritoneal dialysis
- prognostic factors
- single cell
- stem cells
- mesenchymal stem cells
- mild traumatic brain injury
- brain injury
- inflammatory response
- subarachnoid hemorrhage