Hypoxia-mediated YTHDF2 overexpression promotes lung squamous cell carcinoma progression by activation of the mTOR/AKT axis.

Peng XuKang HuPing ZhangZhi-Gang SunNan Zhang

Published in: Cancer cell international (2022)

In brief, the results highlight high-YTHDF2 expression predicted a worse prognosis of LUSC, while hypoxia-mediated YTHDF2 overexpression promotes lung squamous cell carcinoma progression by activation of the mTOR/AKT signaling pathway.

Keyphrases

cell proliferation
squamous cell carcinoma
signaling pathway
pi k akt
poor prognosis
endothelial cells
lymph node metastasis
locally advanced
epithelial mesenchymal transition
induced apoptosis
transcription factor
radiation therapy
binding protein
long non coding rna