Comparison of Rapid Antigen Tests' Performance between Delta (B.1.61.7; AY.X) and Omicron (B.1.1.529; BA1) Variants of SARS-CoV-2: Secondary Analysis from a Serial Home Self-Testing Study.
Apurv SoniCarly HerbertAndreas FilippaiosJohn BroachAndres ColubriNisha FaheyKelsey WoodsJanvi NanavatiColton WrightTaylor OrwigKaren GilliamVik KheterpalThejas SuvarnaChris NowakSummer SchraderHonghuang LinLaurel O'ConnorCaitlin PretzDidem AyturkElizabeth A OrvekJulie FlahivePeter LazarQiming ShiChad J AchenbachRobert Leo MurphyMatthew L RobinsonLaura GibsonPamela StamegnaNathaniel HaferKatherine L LuzuriagaBruce A BartonWilliam HeetderksYukari C ManabeDavid D McManusPublished in: medRxiv : the preprint server for health sciences (2022)
The performance of Ag-RDT is not inferior among individuals infected with the SARS-CoV-2 Omicron variant as compared to the Delta variant. The improvement in sensitivity of Ag-RDT noted with serial testing is consistent between Delta and Omicron variant. Performance of Ag-RDT varies based on duration of RT-PCR+ results and more studies are needed to understand the clinical and public health significance of individuals who are RT-PCR+ for less than 48 hours.