Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice.

Dorit FarfaraMeital SoolimanLimor AvrahamiTabitha Grace RoyalShoshik AmramLea Rozenstein-TsalkovichDorit TrudlerShani Blanga-KanfiHagit Eldar-FinkelmanJens PahnkeHanna RosenmannDan Frenkel

Published in: Journal of neuroinflammation (2023)

Our results suggest the role of τ in exacerbating Aβ pathology in addition to pointing out the potential role of astrocytes in disease progression. Further research of the crosstalk between τ and Aβ in astrocytes may increase our understanding of the role glia cells have in the pathology of AD with the aim of identifying novel therapeutic interventions to an otherwise currently incurable disease.

Keyphrases

long non coding rna
poor prognosis
induced apoptosis
cell cycle arrest
physical activity
metabolic syndrome
wild type
signaling pathway
binding protein
cerebrospinal fluid
climate change
cell proliferation