Inhibition of Pyk2 Improves Cx43 Intercalated Disc Localization, Infarct Size, and Cardiac Function in Rats With Heart Failure.
Li ZhengGaelle SpagnolDevashri R GandhiKanika SharmaVikas KumarKaushik P PatelPaul L SorgenPublished in: Circulation. Heart failure (2023)
Unlike other attempts to decrease Cx43 remodeling after MI-induced heart failure, inhibition of Pyk2 activity maintained Cx43 at the intercalated disc. This may have aided in the reduced infarct size (acute time frame) and improved cardiac function (chronic time frame). Additionally, we provide evidence that Pyk2 is activated following MI in human left ventricle, implicating a novel potential target for therapy in patients with heart failure.
Keyphrases
- heart failure
- drug induced
- endothelial cells
- acute myocardial infarction
- high glucose
- left ventricular
- liver failure
- atrial fibrillation
- acute heart failure
- cardiac resynchronization therapy
- respiratory failure
- diabetic rats
- pulmonary artery
- pulmonary hypertension
- stem cells
- induced pluripotent stem cells
- aortic dissection
- pluripotent stem cells
- mesenchymal stem cells
- human health
- coronary artery disease
- intensive care unit
- bone marrow
- cell therapy
- risk assessment
- hepatitis b virus
- coronary artery
- congenital heart disease
- pulmonary arterial hypertension