DP1 (Prostaglandin D 2 Receptor 1) Activation Protects Against Vascular Remodeling and Vascular Smooth Muscle Cell Transition to Myofibroblasts in Angiotensin II-Induced Hypertension in Mice.
Fangdi ZouYong LiShijie ZhangJian ZhangPublished in: Hypertension (Dallas, Tex. : 1979) (2022)
Our finding revealed a protective role of DP1 in VSMC switch to myofibroblasts by impairing the phosphorylation of MRTF (myocardin-related transcription factor)-A by ROCK-1 through Epac-1/Rap-1/RhoA pathway and thus inhibited the expression of collagen I, fibronectin, ED-A (extra domain A) fibronectin, and vinculin. Thus, DP1 activation has therapeutic potential for vascular fibrosis in hypertension.
Keyphrases
- angiotensin ii
- smooth muscle
- blood pressure
- transcription factor
- single cell
- angiotensin converting enzyme
- vascular smooth muscle cells
- poor prognosis
- emergency department
- cell therapy
- type iii
- high glucose
- diabetic rats
- stem cells
- metabolic syndrome
- oxidative stress
- adipose tissue
- dna binding
- mesenchymal stem cells
- skeletal muscle
- protein kinase
- wound healing