Knockdown of NEAT1 prevents post-stroke lipid droplet agglomeration in microglia by regulating autophagy.

Yongli PanWenqiang XinWei WeiLars TatenhorstIrina GrafAurel Popa-WagnerStefan T GernerSabine E HuberErtugrul KilicDirk M HermannMathias BährHagen B HuttnerThorsten R Doeppner

Published in: Cellular and molecular life sciences : CMLS (2024)

NEAT1 is a key player of LD agglomeration and autophagy stimulation, and NEAT1 knockdown provides a promising therapeutic value against stroke.

Keyphrases

cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
atrial fibrillation
inflammatory response
high throughput
single cell
neuropathic pain
fatty acid
mouse model
spinal cord injury
cerebral ischemia
brain injury
blood brain barrier