Combined inhibition of topoisomerase I and poly(ADP-ribose) polymerase: A synergistic therapeutic strategy for glioblastoma with phosphatase and tensin homolog deficiency.
Olga KimMadison ButlerZach SergiRobert W RobeyMeili ZhangRaj ChariYing PangGuangyang YuWei ZhangHua SongDionne DavisRobert G HawleyXinyu WenHerui WangMartha QuezadoBao TranMythili MerchantAlice RanjanFrank B FurnariJaved KhanMark R GilbertChristopher Ryan MillerMichael M GottesmanYves PommierJing WuPublished in: Neuro-oncology advances (2023)
Our findings provide a proof of concept for the combined treatment with LMP400 and Niraparib in a subset of GBM patients with PTEN deficiency.