Selective anti-CXCR2 receptor blockade by AZD5069 inhibits CXCL8-mediated pro-tumorigenic activity in human thyroid cancer cells in vitro.

F CoperchiniA GrecoE PetrosinoL CroceM TelitiN MarchesiA PascaleB CalìP PignattiF MagriM UddinMario Rotondi

Published in: Journal of endocrinological investigation (2024)

Our findings confirm the involvement of the CXCL8/CXCR2-axis in promoting pro-tumorigenic effects in TC cells, further demonstrating its immunotherapeutic significance in human cancer.

Keyphrases

endothelial cells
induced pluripotent stem cells
induced apoptosis
pluripotent stem cells
anti inflammatory
papillary thyroid
squamous cell carcinoma
cell migration
oxidative stress
cell proliferation
lymph node metastasis
binding protein