EIF4A3 stabilizes the expression of lncRNA AGAP2-AS1 to activate cancer-associated fibroblasts via MyD88/NF-κb signaling.
Qingqing XuTingting ZhaoHonghao HanJiahao FanWei-Ping XiePublished in: Thoracic cancer (2022)
The positive feedback of EIF4A3/AGAP2-AS1/MyD88/NF-κB signaling pathway contributed to the activation of CAFs and exacerbated LC in turn, revealing a novel regulatory axis underlying LC.
Keyphrases
- signaling pathway
- pi k akt
- toll like receptor
- simultaneous determination
- poor prognosis
- lps induced
- induced apoptosis
- nuclear factor
- epithelial mesenchymal transition
- long non coding rna
- mass spectrometry
- oxidative stress
- transcription factor
- inflammatory response
- liquid chromatography
- extracellular matrix
- fluorescent probe
- sensitive detection
- living cells
- immune response
- high resolution
- high resolution mass spectrometry
- single molecule