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ATNT: an enhanced system for expression of polycistronic secondary metabolite gene clusters in Aspergillus niger.

Elena GeibMatthias Brock
Published in: Fungal biology and biotechnology (2017)
This tightly regulated but strongly inducible expression system enables high level production of secondary metabolites most likely even those with toxic potential. Furthermore, this system is compatible with polycistronic gene expression and, thus, suitable for the discovery of novel natural products.
Keyphrases
  • gene expression
  • poor prognosis
  • dna methylation
  • small molecule
  • binding protein
  • genome wide
  • transcription factor
  • high throughput
  • copy number
  • climate change
  • cell wall