Liuwei Dihuang Pills Enhance Osteogenic Differentiation in MC3T3-E1 Cells through the Activation of the Wnt/β-Catenin Signaling Pathway.

Jinlong ZhaoGuihong LiangJunzheng YangHetao HuangYaoxing DouZhuoxu GuJun Liu Ling-Feng ZengWeiyi Yang

Published in: Pharmaceuticals (Basel, Switzerland) (2024)

LWDH pills may upregulate the Wnt/β-catenin signaling pathway to elevate the expression of osteogenic differentiation proteins, including collagen Ⅰ and RUNX2, and to increase the ALP activity in MC3T3-E1 cells for the treatment of OP.

Keyphrases

induced apoptosis
mesenchymal stem cells
cell cycle arrest
stem cells
bone marrow
cell proliferation
poor prognosis
endoplasmic reticulum stress
cell death
oxidative stress
binding protein
combination therapy