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A robust clustering strategy for stratification unveils unique patient subgroups in acutely decompensated cirrhosis.

Sara Palomino-EcheverríaEstefania HuergoAsier Ortega-LegarretaEva M Uson RaposoFerran AguilarCarlos de la Peña-RamirezCristina López-VicarioCarlo AlessandriaWim LalemanAlberto Queiroz FariasRichard MoreauJavier FernandezVicente ArroyoPaolo CaraceniVincenzo LaganiCristina Sánchez-GarridoJoan ClàriaJesper TegnerJonel TrebickaNarsis A KianiNuria PlanellPierre-Emmanuel RautouDavid Gomez-Cabrero
Published in: Journal of translational medicine (2024)
By applying ClustALL to patients with acutely decompensated cirrhosis, we identified three patient clusters. Following these clusters over time offers insights that could guide future clinical trial design. ClustALL is a novel and robust stratification method capable of addressing the multiple challenges of patient stratification in most complex diseases.
Keyphrases
  • case report
  • clinical trial
  • heart failure
  • randomized controlled trial
  • study protocol
  • ejection fraction
  • single cell
  • rna seq
  • open label
  • liver failure
  • hepatitis b virus