Donor leukocyte trafficking during human ex vivo lung perfusion.
Andy Chao Hsuan LeeArianna EdoborThirushan WigakumarMaria LysandrouLaura K JohnstonPhillip McMullenVikranth MirleAshley DiazRyan PiechRebecca RoseMartin JendrisakDiego di SabatoKumaran ShanmugarajahJohn FungJessica DoningtonMaria Lucia MadariagaPublished in: Clinical transplantation (2022)
Early mobilization of innate immune cells occurs in both perfusate and tissue compartments during EVLP, with neutrophils and NK cells returning to baseline and monocytes remaining depleted after 6 h. The immunomodulatory effect of EVLP may provide a therapeutic window to decrease the immunogenicity of lungs prior to transplantation.