Donor leukocyte trafficking during human ex vivo lung perfusion.

Andy Chao Hsuan LeeArianna EdoborThirushan WigakumarMaria LysandrouLaura K JohnstonPhillip McMullenVikranth MirleAshley DiazRyan PiechRebecca RoseMartin JendrisakDiego di SabatoKumaran ShanmugarajahJohn FungJessica DoningtonMaria Lucia Madariaga

Published in: Clinical transplantation (2022)

Early mobilization of innate immune cells occurs in both perfusate and tissue compartments during EVLP, with neutrophils and NK cells returning to baseline and monocytes remaining depleted after 6 h. The immunomodulatory effect of EVLP may provide a therapeutic window to decrease the immunogenicity of lungs prior to transplantation.

Keyphrases

innate immune
nk cells
induced apoptosis
endothelial cells
cell cycle arrest
peripheral blood
dendritic cells
endoplasmic reticulum stress
pluripotent stem cells
signaling pathway
contrast enhanced
magnetic resonance
cell therapy