Contemporary narrative review of treatment options for COVID-19.
Lianhan ShangDavid Chien Boon LyeBin CaoPublished in: Respirology (Carlton, Vic.) (2021)
The coronavirus disease 2019 (COVID-19) pandemic is ongoing and many drugs have been studied in clinical trials. From a pathophysiological perspective, anti-viral drugs may be more effective in the early stage while immunomodulators may be more effective in severe patients in later stages of infection. While drugs such as lopinavir-ritonavir, hydroxychloroquine and azithromycin have proved to be ineffective in randomized controlled trials, corticosteroids, neutralizing monoclonal antibodies, remdesivir, tocilizumab and baricitinib have been reported to benefit certain groups of patients with COVID-19. In this review, we will present the key clinical evidence and progress in promising COVID-19 therapeutics, as well as summarize the experience and lessons learned from the development of the current therapeutics.
Keyphrases
- coronavirus disease
- sars cov
- early stage
- clinical trial
- end stage renal disease
- respiratory syndrome coronavirus
- randomized controlled trial
- small molecule
- newly diagnosed
- ejection fraction
- chronic kidney disease
- rheumatoid arthritis
- drug induced
- prognostic factors
- patient reported outcomes
- squamous cell carcinoma
- systematic review
- antiretroviral therapy
- disease activity
- rectal cancer
- patient reported