Airway Inflammation in Children with Primary Ciliary Dyskinesia.
Scott D SagelOren KupferBrandie D WagnerStephanie D DavisSharon D DellThomas W FerkolJordana E HoppeMargaret RosenfeldKelli M SullivanHarm A W M TiddensMichael R KnowlesMargaret W Leighnull nullPublished in: Annals of the American Thoracic Society (2022)
In this multicenter pediatric PCD cohort, elevated concentrations of sputum proteases and cytokines were associated with impaired lung function and structural damage as determined by chest CT, suggesting that sputum inflammatory measurements could serve as biomarkers in PCD.
Keyphrases
- lung function
- cystic fibrosis
- oxidative stress
- pulmonary tuberculosis
- mycobacterium tuberculosis
- young adults
- computed tomography
- image quality
- chronic obstructive pulmonary disease
- contrast enhanced
- air pollution
- cross sectional
- magnetic resonance imaging
- double blind
- positron emission tomography
- clinical trial
- childhood cancer