Randomised trial of epinephrine dose and flush volume in term newborn lambs.
Deepika SankaranPraveen K ChandrasekharanSylvia F GuginoCarmon KoenigsknechtJustin HelmanJayasree NairBobby MathewMunmun RawatPayam ValiLori NielsenDaniel J TancrediSatyan LakshminrusimhaPublished in: Archives of disease in childhood. Fetal and neonatal edition (2021)
0.03 mg/kg epinephrine dose with 3 mL/kg flush volume is associated with the highest ROSC rate, increases peak plasma epinephrine concentrations and hastens time to ROSC. Clinical trials evaluating optimal epinephrine dose and flush volume are warranted.