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PD-L1 testing based on the SP142 antibody in metastatic triple-negative breast cancer: summary of an expert round-table discussion.

Vicente PegMaría Ángeles López-GarcíaLaura ComermaGloria PeiróTomás García-CaballeroÁngel Concha LópezAna Suárez-GauthierIrune RuizFederico Rojo
Published in: Future oncology (London, England) (2020)
Triple-negative breast cancer (TNBC) is more aggressive than other breast cancer subtypes. TNBC is characterized by increased expression of Programmed Death-ligand 1 (PD-L1), a signal used by many tumors to escape the immune response. Expression of PD-L1 is a positive predictor of response to immunotherapy; therefore, it should be investigated in TNBC in order to select patients who may benefit from anti-PD-L1 therapies. While many PD-L1 assays are available, only the VENTANA platform with the anti-PD-L1 (SP142) antibody is licensed as a companion diagnostic device for selecting patients with metastatic/advanced TNBC who are candidates for treatment with atezolizumab. In this article, we provide a summary of an expert round-table discussion about PD-L1 testing, using the SP142 antibody in metastatic TNBC.
Keyphrases
  • poor prognosis
  • immune response
  • squamous cell carcinoma
  • small cell lung cancer
  • high throughput
  • toll like receptor
  • mass spectrometry
  • single cell
  • smoking cessation
  • childhood cancer