Understanding patterns of invasion: a novel approach to assessment of podoplanin expression in the prediction of lymph node metastasis in oral squamous cell carcinoma.
Ankita SharmaKaren BoazSrikant NatarajanPublished in: Histopathology (2017)
D2-40 expression successfully identifies the motility profile of tumour, irrespective of the pattern of invasion. The presence of larger motile islands in the tumour cohort supports the concept of 'collective cell migration'. Podoplanin also aids evasion of immune responses by inducing platelet aggregation over tumour cells, thereby favouring distant metastasis. A multivariate model using immunohistochemical staining with D2-40 provides greater sensitivity for the prediction of lymph node metastasis.
Keyphrases
- lymph node metastasis
- cell migration
- squamous cell carcinoma
- poor prognosis
- papillary thyroid
- immune response
- induced apoptosis
- cell cycle arrest
- long non coding rna
- genome wide
- dendritic cells
- escherichia coli
- gene expression
- cell death
- cell proliferation
- biofilm formation
- cystic fibrosis
- dna methylation
- endoplasmic reticulum stress
- pseudomonas aeruginosa
- staphylococcus aureus
- pi k akt