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INSM1 Expression in Mesenchymal Tumors and Its Clinicopathological Significance.

Qian ZhangYuting DongMeidong ZhouYujuan GuoLiping LouZhiling QuYiyun ZhengYaqi Duan
Published in: BioMed research international (2022)
The combination of GEO data and immunohistochemistry data indicated that the expression level of INSM1 was higher in AITL compared with normal control, suggesting that INSM1 may be involved in pathogenesis of AITL. The abnormal expression of INSM1 was found in WDLPS, and the positive rate of INSM1 was higher in DDLPS than in WDLPS. INSM1 may be involved in the regulation of liposarcoma development. There were significant differences in the expression of INSM1 between AITL and Hodgkin's lymphoma and WDLPS and DDLPS. These findings may assist in the differential diagnosis of these tumors when common markers are difficult to identify, enriching the diagnostic index system of mesenchymal tumors.
Keyphrases
  • poor prognosis
  • stem cells
  • binding protein
  • bone marrow
  • electronic health record
  • long non coding rna
  • big data
  • data analysis