A Meroisoprenoid, Heptenolides, and C-Benzylated Flavonoids from Sphaerocoryne gracilis ssp. gracilis.
Gasper MaedaJoan J E MunissiSofia LindbladSandra DuffyJerry PelletierVicky M AveryStephen S NyandoroMáté ErdélyiPublished in: Journal of natural products (2020)
A new meroisoprenoid (1), two heptenolides (2 and 3), two C-benzylated flavonoids (4 and 5), and 11 known compounds (6-16) were isolated from leaf, stem bark, and root bark extracts of Sphaerocoryne gracilis ssp. gracilis by chromatographic separation. The structures of the new metabolites 1-5 were established by NMR, IR, and UV spectroscopic and mass spectrometric data analysis. (Z)-Sphaerodiol (7), (Z)-acetylmelodorinol (8), 7-hydroxy-6-hydromelodienone (10), and dichamanetin (15) inhibited the proliferation of Plasmodium falciparum (3D7, Dd2) with IC50 values of 1.4-10.5 μM, although these compounds also showed cytotoxicity against human embryonic kidney HEK-293 cells. None of the compounds exhibited significant disruption in protein translation when assayed in vitro.
Keyphrases
- data analysis
- plasmodium falciparum
- induced apoptosis
- endothelial cells
- high resolution
- magnetic resonance
- molecular docking
- cell cycle arrest
- ms ms
- induced pluripotent stem cells
- liquid chromatography
- endoplasmic reticulum stress
- cell death
- amino acid
- mass spectrometry
- binding protein
- pluripotent stem cells
- pi k akt