Disruption of super-enhancer-driven tumor suppressor gene RCAN1.4 expression promotes the malignancy of breast carcinoma.

Rong DengJun-Hao HuangYan WangLi-Huan ZhouZi-Feng WangBing-Xin HuYu-Hong ChenDong YangJia MaiZhi-Ling LiHai-Liang ZhangYun HuangXiao-Dan PengGong-Kan FengXiao-Feng ZhuJun Tang

Published in: Molecular cancer (2020)

These findings reveal an important role of SEs in facilitating tumour suppression in BC. Considering that the combination of low RCAN1.4 and low RUNX3 expression has worse prognosis, RUNX3-RCAN1.4 axis maybe a novel prognostic biomarker and therapeutic target for BC patients.

Keyphrases

poor prognosis
transcription factor
end stage renal disease
binding protein
ejection fraction
newly diagnosed
genome wide
chronic kidney disease
prognostic factors
gene expression