Mechanistic Modeling of Intrathecal Chemotherapy Pharmacokinetics in the Human Central Nervous System.
Jing LiAndrew WuSeongho KimPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
CNS PBPK modeling, in line with available clinical efficacy data, confirms the therapeutic value of intrathecal chemotherapy with antibody or small molecule drugs for treating neoplastic meningitis and warrants further clinical investigation of intrathecal antibody drugs to treat brain parenchyma tumors. Compared to intraventricular injection, intraventricular 24-h infusion may mitigate neurotoxicity while retaining potential efficacy.
Keyphrases
- small molecule
- locally advanced
- endothelial cells
- cerebrospinal fluid
- low dose
- blood brain barrier
- white matter
- induced pluripotent stem cells
- protein protein
- squamous cell carcinoma
- chemotherapy induced
- pluripotent stem cells
- human health
- risk assessment
- drug induced
- cerebral ischemia
- data analysis
- subarachnoid hemorrhage